PCSK4 anticorps (N-Term)

N° du produit ABIN504511

Détail du produit anti-PCSK4 anticorps

Antigène: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK4 est non-conjugé

Application: Western Blotting (WB)

Séquence: VSSWAVQVSQ GNREVERLAR KFGFVNLGPI FPDGQYFHLR HRGVVQQSLT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PCSK4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PCSK4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 755 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PCSK4

Antigène: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Autre désignation: PCSK4 (PCSK4 Produits)

Synonymes: anticorps PC4, anticorps SPC5, anticorps AI647044, anticorps L21221, anticorps NEC 3, anticorps NEC3, anticorps PCSK4, anticorps pc4, anticorps spc5, anticorps MGC146505, anticorps pcsk4, anticorps proprotein convertase subtilisin/kexin type 4, anticorps proprotein convertase subtilisin/kexin type 4 L homeolog, anticorps PCSK4, anticorps Pcsk4, anticorps pcsk4, anticorps pcsk4.L

Sujet: PCSK4 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK4 plays a role in transcriptional coactivation. PCSK4 may be involved in stabilizing the multiprotein transcription complex.Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR, MIM 136950), and PACE4 (MIM 167405). Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-31 AC027307.5 80201-80231 c 32-257 AY358963.1 32-257 258-655 AK057235.1 452-849 656-2528 AY358963.1 656-2528 2529-2606 AL043305.1 210-287 2607-2674 AA453604.1 1-68 c
Alias Symbols: DKFZp434B217, MGC34749, PC4, SPC5
Protein Interaction Partner: IGF2,
Protein Size: 755

Poids moléculaire: 83 kDa

ID gène: 54760

NCBI Accession: NM_017573, NP_060043

UniProt: Q6UW60