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SOCS1 anticorps (C-Term)

SOCS1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien WB, IHC (p), EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374072
  • Antigène Voir toutes SOCS1 Anticorps
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Épitope
    • 15
    • 12
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 66
    • 36
    • 28
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Humain, Souris, Rat, Boeuf (Vache), Chien
    Hôte
    • 63
    • 5
    • 2
    Chèvre
    Clonalité
    • 66
    • 4
    Polyclonal
    Conjugué
    • 36
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SOCS1 est non-conjugé
    Application
    • 38
    • 23
    • 16
    • 13
    • 13
    • 11
    • 10
    • 9
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Séquence
    C-VLRDYLSSFP FQI
    Specificité
    Recognizes Suppressor Of Cytokine Signaling 1 (SOCS1) at C-term.
    Réactivité croisée (Details)
    Species reactivity (expected):Rat, Canine (Dog) and Bovine.
    Species reactivity (tested):Human, Mouse.
    Purification
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
    Immunogène
    Synthetic peptide from the C-Terminus of Human SOCS1 (NP_003736.1). Genename: SOCS1
    Top Product
    Discover our top product SOCS1 Anticorps primaire
  • Indications d'application
    Peptide ELISA: Limit Dilution: 1/4000. Western blot: 1-3 μg/mL. In transfected HEK293 transiently expressing human SOCS1 bandsof approx.30 kDa and 20 kDa are observed. These bands are not observed in thenon-transfected HEK293. A similar pattern is observed in Mouse Spleen lysates. Thecalculated molecular size is 23.0 kDa according to Human NP_003736.1 and 23.0 kDa
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline buffer, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Autre désignation
    SOCS1 (SOCS1 Produits)
    Synonymes
    anticorps socs1, anticorps zgc:91868, anticorps jab, anticorps cis1, anticorps ssi1, anticorps tip3, anticorps cish1, anticorps ssi-1, anticorps socs-1, anticorps SOCS1, anticorps LOC100228306, anticorps socs1b, anticorps CIS1, anticorps CISH1, anticorps JAB, anticorps SOCS-1, anticorps SSI-1, anticorps SSI1, anticorps TIP3, anticorps Cish1, anticorps Cish7, anticorps Socs-1, anticorps suppressor of cytokine signaling 1a, anticorps suppressor of cytokine signaling 1, anticorps suppressor of cytokine signaling 1 L homeolog, anticorps socs1a, anticorps socs1, anticorps SOCS1, anticorps socs1.L, anticorps Socs1
    Sujet
    SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
    ID gène
    8651
    NCBI Accession
    NP_003736
    UniProt
    O15524
    Pathways
    Signalistation JAK/STAT, Interferon-gamma Pathway, Signalisation TLR, Response to Growth Hormone Stimulus
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