PCSK9
Reactivité: Rat
WB, IHC, IP, ICC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Peptide ELISA: 1/16000. Western Blot: 0.3 μg/mL Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 may function as a proprotein convertase. PCSK9 plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in PCSK9 gene have been associated with a third form of autosomal dominant familial hypercholesterolemia.Synonyms: NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PCSK-9, Proprotein convertase PC9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9