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GAD anticorps (Internal Region)

GAD1 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Porc WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN375070
  • Antigène Voir toutes GAD (GAD1) Anticorps
    GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
    Épitope
    • 15
    • 14
    • 11
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 93
    • 55
    • 51
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Porc
    Hôte
    • 82
    • 16
    • 3
    • 2
    Chèvre
    Clonalité
    • 78
    • 25
    Polyclonal
    Conjugué
    • 57
    • 11
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GAD est non-conjugé
    Application
    • 82
    • 33
    • 31
    • 13
    • 13
    • 13
    • 12
    • 11
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    C-PDSPQRREKL HK
    Specificité
    This antibody is expected to recognize isoform GAD67. There is no cross-reactivity expected with GAD2.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Canine, Bovine, Porcine.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography
    Immunogène
    Peptide with sequence from the internal region of the protein sequence
    Top Product
    Discover our top product GAD1 Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
    Autre désignation
    GAD1 / GAD67 (GAD1 Produits)
    Synonymes
    anticorps CPSQ1, anticorps GAD, anticorps SCP, anticorps GAD-67, anticorps cpsq1, anticorps gad1, anticorps gad1-A, anticorps gad67, anticorps GAD67, anticorps GAD1, anticorps GLUTAMATE DECARBOXYLASE, anticorps GLUTAMATE DECARBOXYLASE 1, anticorps MKP11.30, anticorps MKP11_30, anticorps glutamate decarboxylase, anticorps EP10, anticorps GAD25, anticorps GAD44, anticorps Gad-1, anticorps Gad67, anticorps glutamate decarboxylase 1, anticorps glutamate decarboxylase 1 L homeolog, anticorps glutamate decarboxylase, anticorps glutamate decarboxylase 1b, anticorps GAD1, anticorps gad1.1.L, anticorps GAD, anticorps Gad1, anticorps gad1b
    Sujet
    Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain. There are two isoforms of GAD, GAD65 and GAD67 (65 and 67 kDa, respectively) that are encoded by two different genes. The two isoforms have distinct intraneuronal distribution in the brain. There is 64 % amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA containing secretory vesicles. GAD65 is primarily found in nerve terminals. GAD67 has been thought to be primarily located in the nerve cell body and has been identified as a major autoantigen in type 1 diabetes.Synonyms: 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 1, Glutamate decarboxylase 67 kDa isoform
    Poids moléculaire
    66.9kDa according to NP_000808.2
    ID gène
    2571
    NCBI Accession
    NP_000808
    UniProt
    Q99259
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