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GCH1 anticorps (AA 84-172)

GCH1 Reactivité: Humain WB, ELISA, IHC (p), IP Hôte: Souris Monoclonal 4A12 unconjugated
N° du produit ABIN561018
  • Antigène Voir toutes GCH1 Anticorps
    GCH1 (GTP Cyclohydrolase 1 (GCH1))
    Épitope
    • 15
    • 11
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 84-172
    Reactivité
    • 39
    • 24
    • 10
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 6
    • 1
    Souris
    Clonalité
    • 53
    • 2
    Monoclonal
    Conjugué
    • 21
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GCH1 est non-conjugé
    Application
    • 46
    • 28
    • 18
    • 13
    • 13
    • 5
    • 5
    • 3
    • 3
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    Fonction
    Mouse monoclonal antibody raised against a partial recombinant GCH1.
    Séquence
    ENPQRQGLLK TPWRAASAMQ FFTKGYQETI SDVLNDAIFD EDHDEMVIVK DIDMFSMCEH HLVPFVGKVH IGYLPNKQVL GLSKLARIV
     Réactivité croisée
    Humain
    Attributs du produit
    Antibody Reactive Against Recombinant Protein.
    Immunogène
    GCH1 (NP_000152, 84 a.a. ~ 172 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    4A12
    Isotype
    IgG2a
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Conseil sur la manipulation
    Aliquot to avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." dans: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

    Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." dans: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).

    Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." dans: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

    Pickert, Lim, Weigert, Häussler, Myrczek, Waldner, Labocha, Ferreirós, Geisslinger, Lötsch, Becker, Brüne, Tegeder: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." dans: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).

    Oelze, Knorr, Schuhmacher, Heeren, Otto, Schulz, Reifenberg, Wenzel, Münzel, Daiber: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." dans: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).

    Teng, Du, Xu, Bakhutashvili, Eis, Shi, Pritchard, Konduri: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).

    Schuhmacher, Oelze, Bollmann, Kleinert, Otto, Heeren, Steven, Hausding, Knorr, Pautz, Reifenberg, Schulz, Gori, Wenzel, Münzel, Daiber: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." dans: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).

    Kröller-Schön, Schulz, Wenzel, Kleschyov, Hortmann, Torzewski, Oelze, Renné, Daiber, Münzel: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." dans: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).

    Wenzel, Daiber, Oelze, Brandt, Closs, Xu, Thum, Bauersachs, Ertl, Zou, Förstermann, Münzel: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." dans: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).

    Seujange, Eiam-Ong, Tirawatnapong, Eiam-Ong: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." dans: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).

    Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: "Regulation of tetrahydrobiopterin biosynthesis by shear stress." dans: Circulation research, Vol. 101, Issue 8, pp. 830-8, (2007) (PubMed).

  • Antigène
    GCH1 (GTP Cyclohydrolase 1 (GCH1))
    Autre désignation
    GCH1 (GCH1 Produits)
    Synonymes
    anticorps DYT14, anticorps DYT5, anticorps DYT5a, anticorps GCH, anticorps GTP-CH-1, anticorps GTPCH1, anticorps HPABH4B, anticorps GTP-CH, anticorps GTPCH, anticorps Gch, anticorps MGC89622, anticorps gch1a, anticorps wu:fc16b10, anticorps zgc:195269, anticorps GTP cyclohydrolase 1, anticorps GTP cyclohydrolase 1-like, anticorps GCH1, anticorps Gch1, anticorps gch1, anticorps Weevi_1190, anticorps Halhy_0838, anticorps Sinme_1220, anticorps Sphch_1077, anticorps LOC100136794
    Sujet
    Full Gene Name: GTP cyclohydrolase 1
    Synonyms: DYT14,DYT5,GCH,GTP-CH-1,GTPCH1
    ID gène
    2643
    NCBI Accession
    NM_000161
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