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USP20 anticorps (Middle Region)

USP20 Reactivité: Humain, Souris, Chien, Lapin, Rat, Cheval, Boeuf (Vache), Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN567530
  • Antigène Voir toutes USP20 Anticorps
    USP20 (Ubiquitin Specific Peptidase 20 (USP20))
    Épitope
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 42
    • 12
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Chien, Lapin, Rat, Cheval, Boeuf (Vache), Cobaye
    Hôte
    • 38
    • 4
    • 1
    Lapin
    Clonalité
    • 42
    • 1
    Polyclonal
    Conjugué
    • 22
    • 5
    • 4
    • 4
    • 4
    • 4
    Cet anticorp USP20 est non-conjugé
    Application
    • 30
    • 26
    • 17
    • 4
    • 4
    Western Blotting (WB)
    Séquence
    PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP
    Homologie
    Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against USP20. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human USP20
    Top Product
    Discover our top product USP20 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 913 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    USP20 (Ubiquitin Specific Peptidase 20 (USP20))
    Autre désignation
    USP20 (USP20 Produits)
    Synonymes
    anticorps USP20, anticorps vdu2, anticorps lsfr3a, anticorps LSFR3A, anticorps VDU2, anticorps hVDU2, anticorps 1700055M05Rik, anticorps AI467231, anticorps Vdu2, anticorps im:7151955, anticorps zgc:63661, anticorps universal stress protein, anticorps ubiquitin specific peptidase 20, anticorps ubiquitin specific peptidase 20 L homeolog, anticorps RR_RS15875, anticorps USP20, anticorps usp20, anticorps Usp20, anticorps usp20.L
    Sujet
    USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
    Alias Symbols: KIAA1003, LSFR3A, VDU2
    Protein Interaction Partner: MDFI, MAGEA11, TRIM23, ALAS1, FATE1, BEND5, SPRY2, VAPB, CCDC36, BEND7, RAD17, NEURL4, USP33, USP20, CCP110, ADRB2, PJA1, USP28, USP21, USP15, PLA2G2A, UBC, VHL, HIF1A, VAPA, HERC2P2, PLEKHA7, SYTL4, GPT2, POLDIP3, RGPD5, ATAD3B, MAP7D1, LRRC59, ZNF770, S
    Protein Size: 913
    Poids moléculaire
    102 kDa
    ID gène
    10868
    NCBI Accession
    NM_006676, NP_006667
    UniProt
    Q9Y2K6
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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