CD137 anticorps (FITC)

N° du produit ABIN610408

Détail du produit anti-CD137 anticorps (FITC)

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD137 est conjugé à/à la FITC

Application: ELISA, Flow Cytometry (FACS), Functional Studies (Func)

Specificité: CD137 Molecule of about 35 kd from activated T cells.

Purification: Protein A purified

Immunogène: Ectodomain of recombinant human 4-1BB fusion protein.

Type of Immunogen: Fusion protein

Clone: 4B4-1

Isotype: IgG1 kappa

Information d'application

Indications d'application: Approved: ELISA, Flo, Func

Usage: Function: Blocks binding of CD137 huIg to Raji cells. Immobilized mAb induces TNF a production by monocytes. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Product is photosensitive and should be protected from light.

Stock: 4 °C

Stockage commentaire: Store at 4°C. Do not freeze. Protect from light.

Références pour anticorps anti-CD137 (FITC) (ABIN610408)

Radoja, Saio, Schaer, Koneru, Vukmanovic, Frey: "CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 9, pp. 5042-51, (2001) (PubMed).

Clark, Hynes: "Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization." dans: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14814-8, (1996) (PubMed).

Cobb, Goldsmith: "How MAP kinases are regulated." dans: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 14843-6, (1995) (PubMed).

Boulton, Cobb: "Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies." dans: Cell regulation, Vol. 2, Issue 5, pp. 357-71, (1991) (PubMed).

Détails sur CD137

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Autre désignation: TNFRSF9 / 4-1BB / CD137 (TNFRSF9 Produits)

Synonymes: anticorps TNFRSF9, anticorps zgc:136557, anticorps 4-1BB, anticorps CD137, anticorps CDw137, anticorps ILA, anticorps A930040I11Rik, anticorps AA408498, anticorps AI325004, anticorps Cd137, anticorps Ly63, anticorps tumor necrosis factor receptor superfamily member 9, anticorps TNF receptor superfamily member 9, anticorps tumor necrosis factor receptor superfamily, member 9a, anticorps tumor necrosis factor receptor superfamily, member 9, anticorps TNFRSF9, anticorps tnfrsf9a, anticorps Tnfrsf9

Sujet: Name/Gene ID: TNFRSF9
Family: TNF Receptor

Synonyms: TNFRSF9, 4-1BB ligand receptor, 4-1BB, CD137 antigen, CD137, Homolog of mouse 4-1BB, ILA, Receptor protein 4-1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CDw137

ID gène: 3604

UniProt: Q07011

Pathways: Cancer Immune Checkpoints