PHLDA3 anticorps (C-Term)

N° du produit ABIN615985

Détail du produit anti-PHLDA3 anticorps

Antigène: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PHLDA3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-RARQSLGTGT LVS

Specificité: Recognizes PHLDA3 / TIH1

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: synthetic peptide corresponding to the C Terminus of the protein sequence of Huuman PHLDA3 (NP_036528.1). Genename: PHLDA3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PHLDA3

Antigène: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Autre désignation: PHLDA3 (PHLDA3 Produits)

Synonymes: anticorps TIH1, anticorps Tih1, anticorps si:dz182n13.5, anticorps zgc:92333, anticorps pleckstrin homology like domain family A member 3, anticorps pleckstrin homology like domain, family A, member 3, anticorps pleckstrin homology-like domain, family A, member 3, anticorps PHLDA3, anticorps Phlda3, anticorps phlda3

Sujet: P53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.Synonyms: Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homologue 1, TIH1

ID gène: 23612

NCBI Accession: NP_036528

UniProt: Q9Y5J5