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LAMP1 anticorps

LAMP1 Reactivité: Humain, Souris, Non-Human Primate WB, FACS, ICC, IHC (p), IHC (fro) Hôte: Souris Monoclonal H4A3 unconjugated
N° du produit ABIN638445
  • Antigène Voir toutes LAMP1 Anticorps
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    Reactivité
    • 105
    • 65
    • 37
    • 27
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Non-Human Primate
    Hôte
    • 66
    • 56
    • 25
    • 1
    Souris
    Clonalité
    • 100
    • 48
    Monoclonal
    Conjugué
    • 52
    • 15
    • 15
    • 12
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMP1 est non-conjugé
    Application
    • 92
    • 74
    • 41
    • 34
    • 26
    • 25
    • 24
    • 15
    • 14
    • 13
    • 13
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    The mouse monoclonal antibody H4A3 recognizes an extracellular/luminal epitope of CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
    Réactivité croisée (Details)
    Human, Non-Human Primates, Mouse
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Human PBMC
    Clone
    H4A3
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product LAMP1 Anticorps primaire
  • Indications d'application
    Western blotting: Recommended dilution: 1 μg/mL.
    Immunohistochemistry: Recommended dilution: 2-8 μg/mL.
    Flow cytometry: Intracellular and extracellular staining, recommended dilution: 1-12 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Agent conservateur
    Azide free
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Majer, Vlaskova, Krol, Kalina, Kubanek, Stolnaya, Dvorakova, Elleder, Sikora: "Danon disease: a focus on processing of the novel LAMP2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency." dans: Gene, Vol. 498, Issue 2, pp. 183-95, (2012) (PubMed).

    Mao, Tu, Liu, Qin, Zheng, Chan, Lam, Peiris, Lau: "Inhibition of human natural killer cell activity by influenza virions and hemagglutinin." dans: Journal of virology, Vol. 84, Issue 9, pp. 4148-57, (2010) (PubMed).

    Yu, Gallegos, Marches, Zurawski, Ramilo, García-Sastre, Banchereau, Palucka: "Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines." dans: Blood, Vol. 112, Issue 9, pp. 3671-8, (2008) (PubMed).

    Carlsten, Björkström, Norell, Bryceson, van Hall, Baumann, Hanson, Schedvins, Kiessling, Ljunggren, Malmberg: "DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells." dans: Cancer research, Vol. 67, Issue 3, pp. 1317-25, (2007) (PubMed).

    Tomescu, Chehimi, Maino, Montaner: "NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 4, pp. 2097-104, (2007) (PubMed).

    Marcenaro, Gallo, Martini, Santoro, Griffiths, Aricó, Moretta, Pende: "Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease." dans: Blood, Vol. 108, Issue 7, pp. 2316-23, (2006) (PubMed).

    Deetz, Hebbeler, Propp, Cairo, Tikhonov, Pauza: "Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys." dans: Infection and immunity, Vol. 74, Issue 8, pp. 4505-11, (2006) (PubMed).

    Furuta, Ikeda, Nakayama, Nakamura, Tanaka, Hamasaki, Himeno, Hamilton, August: "Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases." dans: The American journal of pathology, Vol. 159, Issue 2, pp. 449-55, (2001) (PubMed).

    Mane, Marzella, Bainton, Holt, Cha, Hildreth, August: "Purification and characterization of human lysosomal membrane glycoproteins." dans: Archives of biochemistry and biophysics, Vol. 268, Issue 1, pp. 360-78, (1989) (PubMed).

  • Antigène
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    Autre désignation
    CD107a (LAMP1 Produits)
    Synonymes
    anticorps CD107a, anticorps LAMPA, anticorps LGP120, anticorps AI196048, anticorps Lamp-1, anticorps LEP100, anticorps LAMP-1, anticorps LGP-A, anticorps Lgpa, anticorps Lysosome-associated membrane protein 1, anticorps cd107a, anticorps lamp-1, anticorps lamp1, anticorps lampa, anticorps lgp120, anticorps rexp76, anticorps lysosomal associated membrane protein 1, anticorps lysosomal-associated membrane protein 1, anticorps lysosomal-associated membrane protein 1 L homeolog, anticorps LAMP1, anticorps Lamp1, anticorps lamp1.L
    Sujet
    Lysosomal associated membrane protein 1,CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2 % of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.,LAMP-1, LAMPA
    ID gène
    3916
    UniProt
    P11279
    Pathways
    Autophagy
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