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BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) anticorps

BABAM1 Reactivité: Humain WB, IHC (p), FACS Hôte: Lapin Polyclonal RB20468 unconjugated
N° du produit ABIN652514
  • Antigène Voir toutes BRISC and BRCA1 A Complex Member 1 (BABAM1) Anticorps
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Épitope
    • 10
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 116-143
    Reactivité
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 21
    • 4
    • 1
    Lapin
    Clonalité
    • 24
    • 2
    Polyclonal
    Conjugué
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Inconjugué
    Application
    • 23
    • 16
    • 13
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Homologie
    B, M, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the Central region of human HSPC142.
    Clone
    RB20468
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Autre désignation
    HSPC142 (BABAM1 Produits)
    Synonymes
    anticorps merit40, anticorps nba1, anticorps zgc:100909, anticorps c19orf62, anticorps C19orf62, anticorps MERIT40, anticorps NBA1, anticorps C7H19orf62, anticorps 5430437P03Rik, anticorps Merit40, anticorps BRISC and BRCA1 A complex member 1, anticorps BRISC and BRCA1 A complex member 1 L homeolog, anticorps babam1, anticorps BABAM1, anticorps babam1.L, anticorps Babam1
    Sujet
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
    Poids moléculaire
    36560
    ID gène
    29086
    NCBI Accession
    NP_001028721, NP_054892
    UniProt
    Q9NWV8
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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