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CYP27B1 anticorps (C-Term)

CYP27B1 Reactivité: Humain, Rat WB, IHC (p), FACS Hôte: Lapin Polyclonal RB16978 unconjugated
N° du produit ABIN652999
  • Antigène Voir toutes CYP27B1 Anticorps
    CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
    Épitope
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 482-508, C-Term
    Reactivité
    • 15
    • 9
    • 7
    • 4
    Humain, Rat
    Hôte
    • 28
    • 2
    Lapin
    Clonalité
    • 28
    • 2
    Polyclonal
    Conjugué
    • 15
    • 5
    • 5
    • 4
    • 1
    Cet anticorp CYP27B1 est non-conjugé
    Application
    • 19
    • 18
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This CYP27B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1.
    Clone
    RB16978
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:500. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze-thaw cycles.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Date de péremption
    6 months
  • Chiang, Yeh, Huang, Yeh, S Pang, Hsu, Chen, Kuo, Kittaka, Chen, Juang: "25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1α,25(OH)₂D₃." dans: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).

    Schlosser, Carroll, Soler, Pasquini, Mulligan: "Reduced sinonasal levels of 1?-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps." dans: International forum of allergy & rhinology, (2015) (PubMed).

    Mandell, Seedorf, Ryan, Gien, Cramer, Abman: "Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1?-hydroxylase expression in the developing rat." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L1018-26, (2015) (PubMed).

    Mulligan, Nagel, OConnell, Wentzel, Atkinson, Schlosser: "Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis." dans: The Journal of allergy and clinical immunology, Vol. 134, Issue 2, pp. 342-349.e1, (2014) (PubMed).

  • Antigène
    CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
    Autre désignation
    CYP27B1 (CYP27B1 Produits)
    Synonymes
    anticorps cp2b, anticorps cyp1, anticorps cyp1alpha, anticorps cyp27b, anticorps p450c1, anticorps pddr, anticorps vdd1, anticorps vddr, anticorps vddri, anticorps vdr, anticorps CP2B, anticorps CYP1, anticorps CYP1alpha, anticorps CYP27B, anticorps P450c1, anticorps PDDR, anticorps VDD1, anticorps VDDR, anticorps VDDRI, anticorps VDR, anticorps Cyp40, anticorps Cp2b, anticorps Cyp1, anticorps Cyp27b, anticorps Pddr, anticorps Vdd1, anticorps Vddr, anticorps VddrI, anticorps Vdr, anticorps cytochrome P450 family 27 subfamily B member 1, anticorps cytochrome P450, family 27, subfamily B, polypeptide 1, anticorps cytochrome P450, family 27, subfamily b, polypeptide 1, anticorps cyp27b1, anticorps CYP27B1, anticorps Cyp27b1
    Sujet
    CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
    Poids moléculaire
    56504
    ID gène
    1594
    NCBI Accession
    NP_000776
    UniProt
    O15528
    Pathways
    Metabolism of Steroid Hormones and Vitamin D
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