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IRS1 anticorps (pSer307)

IRS1 Reactivité: Humain, Souris, Rat, Chévre ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN749873
  • Antigène Voir toutes IRS1 Anticorps
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Épitope
    • 31
    • 27
    • 23
    • 21
    • 21
    • 21
    • 19
    • 17
    • 16
    • 16
    • 16
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer307
    Reactivité
    • 294
    • 236
    • 212
    • 23
    • 19
    • 18
    • 17
    • 16
    • 15
    • 15
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chévre
    Hôte
    • 291
    • 17
    Lapin
    Clonalité
    • 284
    • 24
    Polyclonal
    Conjugué
    • 140
    • 14
    • 13
    • 12
    • 12
    • 12
    • 12
    • 12
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    Cet anticorp IRS1 est non-conjugé
    Application
    • 175
    • 125
    • 103
    • 92
    • 91
    • 67
    • 57
    • 53
    • 23
    • 20
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This phosphorylation site is homologous to Ser302 in Mouse and Rat.
     Réactivité croisée
    Chévre, Humain, Souris, Rat
    Homologie
    Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser307 [TE(p-S)IT]
    Isotype
    IgG
    Top Product
    Discover our top product IRS1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Zhang, Qin, Zhang, Li, Zhang, Zhao: "Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes." dans: Molecules (Basel, Switzerland), Vol. 23, Issue 10, (2018) (PubMed).

    Luo, Yang, Tang, Yao, Kong, He, Zhou: "Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats." dans: International immunopharmacology, Vol. 28, Issue 1, pp. 744-50, (2015) (PubMed).

  • Antigène
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Autre désignation
    IRS-1 (IRS1 Produits)
    Synonymes
    anticorps HIRS-1, anticorps G972R, anticorps IRS-1, anticorps IRS1IRM, anticorps irs1, anticorps irsu, anticorps IRS1, anticorps irs-1, anticorps irs1-a, anticorps insulin receptor substrate 1, anticorps insulin receptor substrate 2, anticorps insulin receptor substrate 1 S homeolog, anticorps IRS1, anticorps Irs1, anticorps irs2, anticorps irs1.S
    Sujet

    Synonyms: HIRS-1, Insulin receptor substrate 1, IRS-1, IRS1

    Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

    ID gène
    3667
    UniProt
    P35568
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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