ATP2C2 anticorps (N-Term)

N° du produit ABIN783440

Détail du produit anti-ATP2C2 anticorps

Antigène: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP2C2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects ATP2C2 at N-term. At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the amino terminus of human ATP2C2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ATP2C2

Antigène: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Autre désignation: ATP2C2 (ATP2C2 Produits)

Synonymes: anticorps KIAA0703, anticorps MGC146612, anticorps SPCA2, anticorps 1810010G06Rik, anticorps Spca2, anticorps mKIAA0703, anticorps ATPase secretory pathway Ca2+ transporting 2, anticorps ATPase, Ca++ transporting, type 2C, member 2 S homeolog, anticorps ATPase, Ca++ transporting, type 2C, member 2, anticorps ATP2C2, anticorps atp2c2.S, anticorps atp2c2, anticorps Atp2c2

Sujet: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.Synonyms: ATP2C2, ATPase 2C2, Calcium-transporting ATPase type 2C member, EC=3.6.3.8, KIAA0703, SPCA2, Secretory pathway Ca(2+)-ATPase 2

ID gène: 9914

NCBI Accession: NP_055676

UniProt: O75185

Pathways: Ribonucleoside Biosynthetic Process