PIAS2 anticorps (N-Term)

N° du produit ABIN783596

Détail du produit anti-PIAS2 anticorps

Antigène: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIAS2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the amino terminus of human PIAS2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur PIAS2

Antigène: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Autre désignation: PIAS2 (PIAS2 Produits)

Synonymes: anticorps MGC83751, anticorps piasx, anticorps wu:fi05f09, anticorps PIAS2, anticorps 6330408K17Rik, anticorps AI462206, anticorps ARIP3, anticorps AU018068, anticorps Dib, anticorps Miz1, anticorps PIASxalpha, anticorps PIASxb, anticorps PIASxbeta, anticorps SIZ2, anticorps DIP, anticorps MIZ, anticorps MIZ1, anticorps PIASX, anticorps PIASX-ALPHA, anticorps PIASX-BETA, anticorps ZMIZ4, anticorps protein inhibitor of activated STAT 2 L homeolog, anticorps protein inhibitor of activated STAT 2, anticorps protein inhibitor of activated STAT, 2, anticorps pias2.L, anticorps PIAS2, anticorps pias2, anticorps Pias2

Sujet: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.Synonyms: ARIP3, Androgen receptor-interacting protein 3, DAB2-interacting protein, DIP, E3 SUMO-protein ligase PIAS2, Miz1, Msx-interacting zinc finger protein, PIAS-NY protein, PIASX, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2

ID gène: 9063

NCBI Accession: NP_004662

UniProt: O75928

Pathways: Signalistation JAK/STAT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling