NLRP5 anticorps (C-Term)

N° du produit ABIN783707

Détail du produit anti-NLRP5 anticorps

Antigène: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP5 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NLRP5 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide near the carboxy terminus of human NALP5

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NLRP5

Antigène: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Autre désignation: NLRP5 (NLRP5 Produits)

Synonymes: anticorps CLR19.8, anticorps MATER, anticorps NALP5, anticorps PAN11, anticorps PYPAF8, anticorps Mater, anticorps Nalp5, anticorps Op1, anticorps NLR family pyrin domain containing 5, anticorps NLR family, pyrin domain containing 5, anticorps NLRP5, anticorps Nlrp5

Sujet: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.Synonyms: LRR and PYD domains-containing protein 5, MATER, NALP5

ID gène: 126206

NCBI Accession: NP_703148

UniProt: P59047

Pathways: Inflammasome