CDC23 anticorps (Center)

N° du produit ABIN783825

Détail du produit anti-CDC23 anticorps

Antigène: CDC23 (Cell Division Cycle 23 (CDC23))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC23 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 17 amino acid peptide near the center of human APC8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur CDC23

Antigène: CDC23 (Cell Division Cycle 23 (CDC23))

Autre désignation: CDC23 / APC8 (CDC23 Produits)

Synonymes: anticorps CDC23, anticorps anaphase-promoting complex subunit 8, anticorps zgc:56013, anticorps 6030435O18, anticorps D18Ertd243e, anticorps ANAPC8, anticorps APC8, anticorps CUT23, anticorps cell division cycle 23, anticorps cell division cycle protein 23 homolog, anticorps anaphase-promoting complex subunit 8, anticorps CDC23 (cell division cycle 23, yeast, homolog), anticorps cell division cycle 23 S homeolog, anticorps CDC23 cell division cycle 23, anticorps CDC23, anticorps LOC100162672, anticorps LOC100380698, anticorps APC8, anticorps cdc23, anticorps cdc23.S, anticorps Cdc23

Sujet: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.Synonyms: ANAPC8, Anaphase-promoting complex subunit 8, Cell division cycle protein 23 homolog, Cyclosome subunit 8

ID gène: 8697

NCBI Accession: NP_004652

UniProt: Q9UJX2

Pathways: Protein targeting to Nucleus