GRM7 anticorps (pSer862)
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- Antigène Voir toutes GRM7 Anticorps
- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
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Épitope
- pSer862
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Reactivité
- Humain, Rat, Souris, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio), Non-Human Primate
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GRM7 est non-conjugé
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Application
- Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.
- Réactivité croisée (Details)
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Species reactivity (expected):Bovine, Canine, Human, non-Human Primate and Zebrafish.
Species reactivity (tested):Mouse and Rat. - Purification
- Affinity Chromatography.
- Immunogène
- Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser862 of Rat mGluR7.
- Isotype
- IgG
- Top Product
- Discover our top product GRM7 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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- Antigène
- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
- Autre désignation
- mGluR7 / GRM7 (GRM7 Produits)
- Synonymes
- anticorps MGLUR7, anticorps GLUR7, anticorps GPRC1G, anticorps MGLU7, anticorps 6330570A01Rik, anticorps BB176677, anticorps C030018L03, anticorps E130018M02Rik, anticorps Gpr1g, anticorps Gprc1g, anticorps mGluR7, anticorps glutamate metabotropic receptor 7, anticorps glutamate receptor, metabotropic 7, anticorps GRM7, anticorps Grm7
- Sujet
- Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).Synonyms: GPRC1G, MGLUR7, Metabotropic glutamate receptor 7
- ID gène
- 81672
- NCBI Accession
- NP_112302
- Pathways
- Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour
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