NMDAR2A anticorps (pTyr1325)

N° du produit ABIN784606

Détail du produit anti-NMDAR2A anticorps

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Épitope: pTyr1325

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NMDAR2A est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~180k NMDAR NR2A-subunit protein phosphorylated at Tyr1325 in Western blots. Immunolabeling is completely blocked by blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.

Réactivité croisée (Details): Species reactivity (expected):Bovine and CanineSpecies reactivity (tested):Mouse and Rat.

Purification: Affinity Chromatography.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1325 of NMDA NR2A.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur NMDAR2A

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Abstract: GRIN2A Produits

Synonymes: anticorps NMDAR2A, anticorps nr2a, anticorps GRIN2A, anticorps EPND, anticorps GluN2A, anticorps NR2A, anticorps glutamate ionotropic receptor NMDA type subunit 2A, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog, anticorps glutamate receptor ionotropic, NMDA 2A, anticorps glutamate receptor, ionotropic, NMDA2A (epsilon 1), anticorps GRIN2A, anticorps grin2a.L, anticorps LOC100438553, anticorps Grin2a

Sujet: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). Channels with physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Recently, phosphorylation of Tyrosine 1325 of the NR2A subunit has been shown to be increased in human brain tissue sections from HIV-infected individuals with encephalitis (King et al., 2010). In addition, Tyr1325 phosphorylation has been linked with depression-related behavior (Taniguchi et al., 2009).Synonyms: GRIN2A, Glutamate [NMDA] Receptor subunit epsilon-1, NMDAR2A, NR2A

ID gène: 24409

NCBI Accession: NP_036705

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity