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CD103 anticorps (FITC)

ITGAE Reactivité: Humain, Non-Human Primate FACS Hôte: Souris Monoclonal Ber-ACT8 FITC
N° du produit ABIN810081
  • Antigène Voir toutes CD103 (ITGAE) Anticorps
    CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
    Reactivité
    • 74
    • 38
    • 8
    • 5
    • 4
    • 3
    Humain, Non-Human Primate
    Hôte
    • 41
    • 40
    • 16
    • 15
    • 4
    Souris
    Clonalité
    • 84
    • 32
    Monoclonal
    Conjugué
    • 44
    • 13
    • 12
    • 8
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD103 est conjugé à/à la FITC
    Application
    • 58
    • 38
    • 26
    • 24
    • 22
    • 15
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody Ber-ACT8 recognizes an extracellular epitope of CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    HTLV-1 induced human T cell line MAPS16
    Clone
    Ber-ACT8
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ITGAE Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Zhang, Bertucci, Ramsey-Goldman, Burt, Datta et al.: "Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 10, pp. 6346-58, (2009) (PubMed).

    Jaensson, Uronen-Hansson, Pabst, Eksteen, Tian, Coombes, Berg, Davidsson, Powrie, Johansson-Lindbom, Agace: "Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans." dans: The Journal of experimental medicine, Vol. 205, Issue 9, pp. 2139-49, (2008) (PubMed).

    Cardoso, Garlet, Moreira, Júnior, Rossi, Silva: "Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis." dans: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 311-8, (2008) (PubMed).

    Kost, Holden, Mann: "Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis." dans: Cytometry. Part B, Clinical cytometry, Vol. 74, Issue 5, pp. 282-6, (2008) (PubMed).

    Sigmundsdottir, Johnston, Gudjonsson, Bjarnason, Valdimarsson: "Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin." dans: Experimental dermatology, Vol. 13, Issue 7, pp. 426-34, (2004) (PubMed).

    León, Roy: "Isolation of human small bowel intraepithelial lymphocytes by annexin V-coated magnetic beads." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 6, pp. 804-9, (2004) (PubMed).

    Brandes, Willimann, Lang, Nam, Jin, Brenner, Morita, Moser: "Flexible migration program regulates gamma delta T-cell involvement in humoral immunity." dans: Blood, Vol. 102, Issue 10, pp. 3693-701, (2003) (PubMed).

    Poles, Barsoum, Yu, Yu, Sun, Daly, He, Mehandru, Talal, Markowitz, Hurley, Ho, Zhang: "Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy." dans: Journal of virology, Vol. 77, Issue 19, pp. 10456-67, (2003) (PubMed).

    French, Cresswell, Wong, Seymour, Charnley, Kirby: "T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?" dans: British journal of cancer, Vol. 87, Issue 9, pp. 1034-41, (2002) (PubMed).

  • Antigène
    CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
    Autre désignation
    CD103 (ITGAE Produits)
    Synonymes
    anticorps A530055J10, anticorps CD103, anticorps aM290, anticorps alpha-E1, anticorps alpha-M290, anticorps HUMINAE, anticorps integrin alpha E, epithelial-associated, anticorps integrin subunit alpha E, anticorps Itgae, anticorps ITGAE
    Sujet
    Integrin subunit alpha E,CD103 / integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.,Integrin alpha E, ITGAE
    ID gène
    3682
    UniProt
    P38570
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