DC-SIGN/CD209 anticorps (AA 389-393)

N° du produit ABIN871532

Détail du produit anti-DC-SIGN/CD209 anticorps

Antigène: DC-SIGN/CD209 (CD209) (CD209)

Épitope: AA 389-393

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DC-SIGN/CD209 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody detects endogenous level of total CD209 (DC-SIGN) protein.

Purification: Affinity purified

Immunogène: Peptide sequence around AA 389-393 ( E-Q-F-L-S ) derived from Human CD209 (DC-SIGN) . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur DC-SIGN/CD209

Antigène: DC-SIGN/CD209 (CD209) (CD209)

Autre désignation: CD209 (DC-SIGN) (CD209 Produits)

Synonymes: anticorps CDSIGN, anticorps CLEC4L, anticorps DC-SIGN, anticorps DC-SIGN1, anticorps cd209, anticorps CLEC4M, anticorps si:ch211-224h1.3, anticorps CD209, anticorps CIRE, anticorps Dcsign, anticorps SIGN-R1, anticorps SIGNR5, anticorps Cd209, anticorps CD209 molecule, anticorps CD209a antigen, anticorps CD209 antigen-like protein D, anticorps CD209c molecule, anticorps CD209 antigen, anticorps CD209, anticorps cd209, anticorps Cd209a, anticorps LOC100529184, anticorps Cd209c, anticorps LOC100460708, anticorps LOC105484282

Sujet: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

Poids moléculaire: 46 kDa

ID gène: 30835

NCBI Accession: NP_066978

UniProt: Q9NNX6