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Tyrosine Hydroxylase anticorps (AA 29-33)

TH Reactivité: Rat, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN871616
  • Antigène Voir toutes Tyrosine Hydroxylase (TH) Anticorps
    Tyrosine Hydroxylase (TH)
    Épitope
    • 17
    • 15
    • 12
    • 10
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 29-33
    Reactivité
    • 113
    • 106
    • 95
    • 11
    • 10
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat, Souris
    Hôte
    • 107
    • 26
    • 7
    • 4
    • 2
    Lapin
    Clonalité
    • 110
    • 36
    Polyclonal
    Conjugué
    • 95
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Tyrosine Hydroxylase est non-conjugé
    Application
    • 101
    • 67
    • 40
    • 22
    • 21
    • 18
    • 17
    • 16
    • 14
    • 13
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    The antibody detects endogenous levels of total Tyrosine Hydroxylase protein.
    Purification
    Affinity purified
    Immunogène
    Peptide sequence around AA 29-33 (V-T-S-P-R) derived from Mouse Tyrosine Hydroxylase. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product TH Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène
    Tyrosine Hydroxylase (TH)
    Autre désignation
    Tyrosine Hydroxylase (TH Produits)
    Synonymes
    anticorps DYT14, anticorps DYT5b, anticorps TYH, anticorps The, anticorps CG10118, anticorps DH65B, anticorps DTH, anticorps Dmel\\CG10118, anticorps Pale, anticorps Ple, anticorps TH, anticorps Th, anticorps VII, anticorps dTH1, anticorps dTH65B, anticorps pale/ple, anticorps th, anticorps dyt14, anticorps dyt5b, anticorps tyh, anticorps tyrosine hydroxylase, anticorps pale, anticorps tyrosine 3-monooxygenase, anticorps tyrosine hydroxylase S homeolog, anticorps TH, anticorps Th, anticorps ple, anticorps th, anticorps th.S, anticorps LOC100008895
    Sujet
    Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.
    Poids moléculaire
    55-60 kDa
    ID gène
    7054
    NCBI Accession
    NP_954986
    UniProt
    P07101
    Pathways
    Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
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