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CDK4 anticorps (AA 295-299)

CDK4 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN871659
  • Antigène Voir toutes CDK4 Anticorps
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Épitope
    • 23
    • 16
    • 16
    • 9
    • 9
    • 9
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 295-299
    Reactivité
    • 120
    • 76
    • 55
    • 19
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 108
    • 34
    • 2
    • 1
    Lapin
    Clonalité
    • 107
    • 37
    Polyclonal
    Conjugué
    • 84
    • 11
    • 11
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CDK4 est non-conjugé
    Application
    • 122
    • 55
    • 37
    • 31
    • 21
    • 19
    • 16
    • 15
    • 14
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    The antibody detects endogenous levels of total CDK4 protein.
    Purification
    Affinity purified
    Immunogène
    Peptide sequence around AA 295-299 (L-H-K-D-E) derived from Human CDK4. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product CDK4 Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Autre désignation
    CDK4 (CDK4 Produits)
    Synonymes
    anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
    Sujet
    Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins . The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase . The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression . In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle .
    Poids moléculaire
    34 kDa
    ID gène
    1019
    NCBI Accession
    NP_000066
    UniProt
    P11802
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
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