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GABRA3 anticorps (AA 33-37)

GABRA3 Reactivité: Humain, Rat, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN871662
  • Antigène Voir toutes GABRA3 Anticorps
    GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
    Épitope
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 33-37
    Reactivité
    • 27
    • 25
    • 21
    • 8
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 30
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 32
    • 1
    Polyclonal
    Conjugué
    • 26
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GABRA3 est non-conjugé
    Application
    • 20
    • 12
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    The antibody detects endogenous level of total GABA A Receptor a3 protein.
    Purification
    Affinity purified
    Immunogène
    Peptide sequence around AA 33-37 (R-R-Q-E-P) derived from Rat GABA A Receptor a3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product GABRA3 Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène
    GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
    Abstract
    GABRA3 Produits
    Synonymes
    anticorps GABRA3, anticorps Gabra-3, anticorps si:ch211-113k9.1, anticorps gamma-aminobutyric acid type A receptor alpha3 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, alpha 3, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3, anticorps gamma-aminobutyric acid receptor subunit alpha-3, anticorps GABRA3, anticorps gabra3, anticorps Gabra3, anticorps LOC100653496
    Sujet
    GABA (g-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation
    Poids moléculaire
    51 kDa
    ID gène
    24947
    NCBI Accession
    NP_058765
    UniProt
    P20236
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