TAZ anticorps (AA 386-390)

N° du produit ABIN871734

Détail du produit anti-TAZ anticorps

Antigène: TAZ (Tafazzin (TAZ))

Épitope: AA 386-390

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAZ est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody detects endogenous level of total TAZ protein.

Purification: Affinity purified

Immunogène: Peptide sequence around AA 386-390 (V-E-S-A-L) derived from Human TAZ. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur TAZ

Antigène: TAZ (Tafazzin (TAZ))

Autre désignation: TAZ (TAZ Produits)

Synonymes: anticorps wu:fb39f12, anticorps zgc:91803, anticorps MGC54019, anticorps TAZ, anticorps taz, anticorps GB11956, anticorps Afu2g13960, anticorps BTHS, anticorps CMD3A, anticorps EFE, anticorps EFE2, anticorps G4.5, anticorps LVNCX, anticorps Taz1, anticorps 5031411C02Rik, anticorps 9130012G04Rik, anticorps AW107266, anticorps AW552613, anticorps tafazzin, anticorps tafazzin L homeolog, anticorps tafazzin homolog, anticorps TAZ, anticorps taz, anticorps taz.L, anticorps LOC550948, anticorps AFUA_2G13960, anticorps AOR_1_318014, anticorps Tsp_06712, anticorps Taz

Sujet: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Poids moléculaire: 49 kDa

ID gène: 25937

NCBI Accession: NP_001161

UniProt: Q9GZV5