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KAP1 anticorps (AA 827-831)

TRIM28 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN871735
  • Antigène Voir toutes KAP1 (TRIM28) Anticorps
    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
    Épitope
    • 29
    • 15
    • 11
    • 10
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 827-831
    Reactivité
    • 115
    • 53
    • 49
    • 10
    • 9
    • 8
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 115
    • 16
    • 4
    Lapin
    Clonalité
    • 108
    • 27
    Polyclonal
    Conjugué
    • 64
    • 10
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp KAP1 est non-conjugé
    Application
    • 86
    • 42
    • 41
    • 27
    • 26
    • 23
    • 22
    • 21
    • 19
    • 15
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    The antibody detects endogenous level of total TIF1b protein.
    Purification
    Affinity purified
    Immunogène
    Peptide sequence around AA 827-831 (L-S-G-G-P) derived from Human TIF1b. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product TRIM28 Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène
    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
    Autre désignation
    TIF1beta (TRIM28 Produits)
    Synonymes
    anticorps KAP1, anticorps RNF96, anticorps TF1B, anticorps TIF1B, anticorps TRIM28, anticorps kap1, anticorps rnf96, anticorps tf1b, anticorps tif1b, anticorps AA408787, anticorps KAP-1, anticorps KRIP-1, anticorps Tif1b, anticorps Tif1beta, anticorps Kap1, anticorps Krip1, anticorps TIF1BETA, anticorps tripartite motif containing 28, anticorps tripartite motif containing 28 L homeolog, anticorps tripartite motif-containing 28, anticorps TRIM28, anticorps trim28.L, anticorps Trim28
    Sujet
    Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.
    Poids moléculaire
    110 kDa
    ID gène
    10155
    NCBI Accession
    NP_005753
    UniProt
    Q13263
    Pathways
    Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus
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