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ADAM11 anticorps (AA 351-450) (Alexa Fluor 555)

ADAM11 Reactivité: Humain, Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 555
N° du produit ABIN881266
  • Antigène Voir toutes ADAM11 Anticorps
    ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
    Épitope
    • 14
    • 8
    • 7
    • 6
    • 2
    • 1
    AA 351-450
    Reactivité
    • 38
    • 21
    • 6
    • 5
    Humain, Souris
    Hôte
    • 36
    • 2
    Lapin
    Clonalité
    • 37
    • 1
    Polyclonal
    Conjugué
    • 10
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADAM11 est conjugé à/à la Alexa Fluor 555
    Application
    • 37
    • 18
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ADAM11
    Isotype
    IgG
    Top Product
    Discover our top product ADAM11 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
    Autre désignation
    ADAM11 (ADAM11 Produits)
    Synonymes
    anticorps DKFZp459F101, anticorps AW060611, anticorps Mdc, anticorps MDC, anticorps mdc, anticorps mdc11a, anticorps xMDC11, anticorps ADAM metallopeptidase domain 11, anticorps a disintegrin and metallopeptidase domain 11, anticorps ADAM metallopeptidase domain 11 L homeolog, anticorps ADAM11, anticorps adam11, anticorps Adam11, anticorps adam11.L
    Sujet

    Synonyms: A disintegrin and metalloproteinase domain 11, ADA11_HUMAN, MDC, Metalloproteinase like, disintegrin like, and cysteine rich protein.

    Background: ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.

    ID gène
    4185
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