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CD1a anticorps (FITC)

CD1a Reactivité: Humain FACS Hôte: Souris Monoclonal HI149 FITC
N° du produit ABIN94019
  • Antigène Voir toutes CD1a Anticorps
    CD1a
    Reactivité
    • 174
    • 23
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 115
    • 63
    Souris
    Clonalité
    • 136
    • 41
    • 1
    Monoclonal
    Conjugué
    • 72
    • 13
    • 12
    • 9
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD1a est conjugé à/à la FITC
    Application
    • 109
    • 62
    • 43
    • 43
    • 32
    • 28
    • 12
    • 11
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody HI149 reacts with an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
    Réactivité croisée (Details)
    Other not tested, Human
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Human thymocytes
    Clone
    HI149
    Isotype
    IgG1
    Top Product
    Discover our top product CD1a Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Mayer, Irschick, Moser, Wurm, Huemer, Romani, Irschick: "Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers." dans: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4459-67, (2007) (PubMed).

    Angel, Lala, Chen, Edgar, Ostrovsky, Dunbar: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." dans: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).

    Perros, Dorfmüller, Souza, Durand-Gasselin, Mussot, Mazmanian, Hervé, Emilie, Simonneau, Humbert: "Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension." dans: The European respiratory journal, Vol. 29, Issue 3, pp. 462-8, (2007) (PubMed).

    Demedts, Brusselle, Vermaelen, Pauwels: "Identification and characterization of human pulmonary dendritic cells." dans: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, (2005) (PubMed).

    Chen, Murakami, Oppenheim, Howard: "Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking." dans: Blood, Vol. 106, Issue 7, pp. 2409-16, (2005) (PubMed).

    Kirsch, Zeyda, Stuhlmeier, Grisar, Smolen, Watschinger, Stulnig, Hörl, Zlabinger, Säemann: "The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function." dans: Arthritis research & therapy, Vol. 7, Issue 3, pp. R694-703, (2005) (PubMed).

    Hunger, Sieling, Ochoa, Sugaya, Burdick, Rea, Brennan, Belisle, Blauvelt, Porcelli, Modlin: "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells." dans: The Journal of clinical investigation, Vol. 113, Issue 5, pp. 701-8, (2004) (PubMed).

    McKenna, Asplund, Kroft: "Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry." dans: Leukemia & lymphoma, Vol. 45, Issue 2, pp. 277-85, (2004) (PubMed).

    Säemann, Parolini, Böhmig, Kelemen, Krieger, Neumüller, Knarr, Kammlander, Hörl, Diakos, Stuhlmeier, Zlabinger: "Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells." dans: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 238-46, (2002) (PubMed).

  • Antigène
    CD1a
    Autre désignation
    CD1a (CD1a Produits)
    Synonymes
    anticorps CD1, anticorps FCB6, anticorps HTA1, anticorps R4, anticorps T6, anticorps CD1A, anticorps CD1a molecule, anticorps CD1 antigen, anticorps T-cell surface glycoprotein CD1a, anticorps CD1A, anticorps CD1.1, anticorps LOC100156095, anticorps LOC101111409
    Sujet
    CD1a molecule,CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.,T6, Leu-6, HTA1, FCB6
    ID gène
    909
    UniProt
    P06126
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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