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CD6 anticorps

CD6 Reactivité: Humain WB, FACS, IP, IHC (p) Hôte: Souris Monoclonal MEM-98 unconjugated
N° du produit ABIN94206
  • Antigène Voir toutes CD6 Anticorps
    CD6
    Reactivité
    • 85
    • 29
    • 21
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 54
    • 36
    • 4
    Souris
    Clonalité
    • 60
    • 34
    Monoclonal
    Conjugué
    • 38
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD6 est non-conjugé
    Application
    • 54
    • 53
    • 34
    • 18
    • 18
    • 15
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    The antibody MEM-98 reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone).
    Clone
    MEM-98
    Isotype
    IgG1
    Top Product
    Discover our top product CD6 Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 2 μg/mL.
    Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: spleen.
    Western blotting: Non-reducing conditions.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Castro, Oliveira, Nunes, Fabre, Barbosa, Peixoto, Brown, Parnes, Bismuth, Moreira, Rocha, Carmo: "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4351-61, (2007) (PubMed).

    Hassan, Simmonds, Clarkson, Hanrahan, Puklavec, Bomb, Barclay, Brown: "CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76." dans: Molecular and cellular biology, Vol. 26, Issue 17, pp. 6727-38, (2006) (PubMed).

    Bazil, Stefanová, Hilgert, Kristofová, Van?k, Bukovský, Horejsí: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." dans: Folia biologica, Vol. 35, Issue 5, pp. 289-97, (1990) (PubMed).

  • Antigène
    CD6
    Autre désignation
    CD6 (CD6 Produits)
    Synonymes
    anticorps TP120, anticorps OX52, anticorps CD6 antigen, anticorps CD6 molecule, anticorps Cd6 molecule, anticorps Cd6, anticorps CD6
    Sujet
    CD6 Molecule,CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.,T12, TP120
    ID gène
    923
    UniProt
    P30203
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