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HLA-E anticorps

HLA-E Reactivité: Humain, Non-Human Primate WB, IHC (p) Hôte: Souris Monoclonal MEM-E-02 unconjugated
N° du produit ABIN94352
  • Antigène Voir toutes HLA-E Anticorps
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Reactivité
    • 70
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Non-Human Primate
    Hôte
    • 44
    • 27
    Souris
    Clonalité
    • 46
    • 25
    Monoclonal
    Conjugué
    • 30
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HLA-E est non-conjugé
    Application
    • 42
    • 29
    • 20
    • 13
    • 13
    • 11
    • 10
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on the surface of all human cell types.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Recombinant human HLA-E denaturated heavy chain.
    Clone
    MEM-E-02
    Isotype
    IgG1
    Top Product
    Discover our top product HLA-E Anticorps primaire
  • Indications d'application
    Immunohistochemistry (paraffin sections): Recommended dilution: 5-10 μg/mL, positive control: human placenta, heat antigen retrieval (sodium citrate), incubation with mAb: 1 hour / RT, detection DAB.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Platonova, Cherfils-Vicini, Damotte, Crozet, Vieillard, Validire, André, Dieu-Nosjean, Alifano, Régnard, Fridman, Sautès-Fridman, Cremer: "Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma." dans: Cancer research, Vol. 71, Issue 16, pp. 5412-22, (2011) (PubMed).

    Lo Monaco, Tremante, Cerboni, Melucci, Sibilio, Zingoni, Nicotra, Natali, Giacomini: "Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells." dans: Neoplasia (New York, N.Y.), Vol. 13, Issue 9, pp. 822-30, (2011) (PubMed).

    Dambaeva, Bondarenko, Grendell, Kravitz, Durning, Golos: "Non-classical MHC-E (Mamu-E) expression in the rhesus monkey placenta." dans: Placenta, Vol. 29, Issue 1, pp. 58-70, (2008) (PubMed).

    Menier, Saez, Horejsi, Martinozzi, Krawice-Radanne, Bruel, Le Danff, Reboul, Hilgert, Rabreau, Larrad, Pla, Carosella, Rouas-Freiss: "Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules." dans: Human immunology, Vol. 64, Issue 3, pp. 315-26, (2003) (PubMed).

  • Antigène
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Autre désignation
    HLA-E (HLA-E Produits)
    Synonymes
    anticorps EA1.2, anticorps EA2.1, anticorps HLA-6.2, anticorps MHC, anticorps QA1, anticorps major histocompatibility complex, class I, E, anticorps HLA-E, anticorps PATR-E
    Sujet
    Major histocompatibility complex, class I, E,HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).,HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E
    ID gène
    3133
    UniProt
    P13747
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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