COPS7A anticorps (C-Term)

N° du produit ABIN951662

Détail du produit anti-COPS7A anticorps

Antigène: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Épitope: AA 244-274, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS7A est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to COPS7A.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 244-274 amino acids from the C-terminal region of human COPS7A

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur COPS7A

Antigène: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Autre désignation: COPS7A (COPS7A Produits)

Sujet: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.Synonyms: COP9 signalosome complex subunit 7a, CSN7A, DERP10, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, SGN7a, Signalosome subunit 7a

Poids moléculaire: 30277 Da

ID gène: 50813

NCBI Accession: NP_001157565

Pathways: Cycle Cellulaire