MAP3K4 anticorps (Middle Region)

N° du produit ABIN953298

Détail du produit anti-MAP3K4 anticorps

Antigène: MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

Épitope: AA 1065-1097, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to MEKK4.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 1065-1097 amino acids from the Central region of human MEKK4 Genename: MAP3K4

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MAP3K4

Antigène: MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

Autre désignation: MAP3K4 (MAP3K4 Produits)

Synonymes: anticorps MAPKKK4, anticorps MEKK4, anticorps MTK1, anticorps PRO0412, anticorps D17Rp17, anticorps D17Rp17e, anticorps MEKK 4, anticorps Mek4b, anticorps Mekk4, anticorps RP17, anticorps Rp17a, anticorps Tas, anticorps mKIAA0213, anticorps mitogen activated protein kinase kinase kinase 4, anticorps mitogen-activated protein kinase kinase kinase 4, anticorps Map3k4, anticorps MAP3K4

Sujet: The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.Synonyms: MAP three kinase 1, MAPK/ERK kinase kinase 4, MAPKKK4, MEKK4, MTK1, Mitogen-activated protein kinase kinase kinase 4

Poids moléculaire: 181685 Da

ID gène: 4216

NCBI Accession: NP_005913

Pathways: Signalisation MAPK