Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PF4 anticorps

PF4 Reactivité: Humain WB, EIA Hôte: Souris Monoclonal KKO unconjugated
N° du produit ABIN954177
  • Antigène Voir toutes PF4 Anticorps
    PF4 (Platelet Factor 4 (PF4))
    Reactivité
    • 66
    • 14
    • 12
    • 1
    Humain
    Hôte
    • 66
    • 18
    • 3
    • 1
    • 1
    Souris
    Clonalité
    • 69
    • 20
    Monoclonal
    Conjugué
    • 45
    • 15
    • 12
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PF4 est non-conjugé
    Application
    • 65
    • 35
    • 34
    • 14
    • 11
    • 9
    • 9
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody is specific for Human Platelet Factor IV/heparin complexes. AM31851PU-N (clone KKO), unlike AM31850PU-N (clone RTO) which binds PF4 alone, is specific for PF4/heparin complexes and is seen to have similar binding properties as auto-antibodies found in HIT/HITT.
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Protein G Chromatography of Ascitic fluid
    Immunogène
    Human Factor IV purified from the supernatant of Thrombin activated platelets.
    Clone
    KKO
    Isotype
    IgG2b
    Top Product
    Discover our top product PF4 Anticorps primaire
  • Indications d'application
    ELISA: Use at 0.08 μg/mL following coating plate with PF4/ heparin complex. This can be done by incubating PF4 with an excess of heparin (100-200 U/mL), while coating the plate.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    PF4 (Platelet Factor 4 (PF4))
    Autre désignation
    Platelet Factor 4 / PF4 (PF4 Produits)
    Synonymes
    anticorps CXCL4, anticorps PF-4, anticorps SCYB4, anticorps Cxcl4, anticorps Scyb4, anticorps Pf4a, anticorps RATPF4A, anticorps PF4A, anticorps CXCL4L1, anticorps CXCL4V1, anticorps PF4-ALT, anticorps SCYB4V1, anticorps PF4, anticorps platelet factor 4, anticorps platelet factor 4 variant 1, anticorps PF4, anticorps Pf4, anticorps LOC703451, anticorps PF4V1, anticorps LOC100524373, anticorps LOC102181854, anticorps LOC100630489
    Sujet
    Platelet Factor IV (PF4) is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT) is a life-threatening complication that manifests itself in a small population of patients exposed to intravenous-heparin. It is characterized by the production of PF4/heparin auto-antibodies. These auto-antibodies bind the PF4/heparin complexes and subsequently bind the FCGIIa receptor on the platelets surface through their Fc region. This activates the platelets and can initiate clot formation.Synonyms: C-X-C motif chemokine 4, CXCL4, Iroplact, Oncostatin-A, PF-4, SCYB4
    ID gène
    5196
    NCBI Accession
    NP_002610
    UniProt
    P02776
Vous êtes ici:
Support technique