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APP anticorps (N-Term)

APP Reactivité: Humain, Rat WB, IHC (p) Polyclonal unconjugated
N° du produit ABIN965581
  • Antigène Voir toutes APP Anticorps
    APP (Amyloid beta (A4) Precursor Protein (APP))
    Épitope
    • 30
    • 28
    • 24
    • 24
    • 21
    • 18
    • 12
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 18-32, N-Term
    Reactivité
    • 275
    • 121
    • 114
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    Veuillez nous consulter SVP
    Clonalité
    • 257
    • 63
    Polyclonal
    Conjugué
    • 149
    • 31
    • 23
    • 23
    • 12
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APP est non-conjugé
    Application
    • 213
    • 158
    • 93
    • 52
    • 52
    • 51
    • 41
    • 41
    • 30
    • 26
    • 16
    • 11
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Immunogène
    A synthetic peptide corresponding to a sequence at the N-terminal of human APP (18-32 aa), identical to the related mouse and rat sequence.
    Top Product
    Discover our top product APP Anticorps primaire
  • Restrictions
    For Research Use only
  • Reconstitution
    0.2ml of distilled water will yield a concentration of 500µg/ml.
    Buffer
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Stock
    -20 °C
  • Duce, Tsatsanis, Cater, James, Robb, Wikhe, Leong, Perez, Johanssen, Greenough, Cho, Galatis, Moir, Masters, McLean, Tanzi, Cappai, Barnham, Ciccotosto, Rogers, Bush: "Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease." dans: Cell, Vol. 142, Issue 6, pp. 857-67, (2010) (PubMed).

    Priller, Bauer, Mitteregger, Krebs, Kretzschmar, Herms: "Synapse formation and function is modulated by the amyloid precursor protein." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 27, pp. 7212-21, (2006) (PubMed).

    Wang, Ha: "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain." dans: Molecular cell, Vol. 15, Issue 3, pp. 343-53, (2004) (PubMed).

    Turner, OConnor, Tate, Abraham: "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory." dans: Progress in neurobiology, Vol. 70, Issue 1, pp. 1-32, (2003) (PubMed).

  • Antigène
    APP (Amyloid beta (A4) Precursor Protein (APP))
    Autre désignation
    APP (APP Produits)
    Synonymes
    anticorps AAA, anticorps ABETA, anticorps ABPP, anticorps AD1, anticorps APPI, anticorps CTFgamma, anticorps CVAP, anticorps PN-II, anticorps PN2, anticorps aaa, anticorps abeta, anticorps abpp, anticorps ad1, anticorps appi, anticorps ctfgamma, anticorps cvap, anticorps pn2, anticorps APP, anticorps APP-like, anticorps APPL, anticorps Abeta, anticorps BcDNA:GH04413, anticorps CG7727, anticorps Dmel\\CG7727, anticorps EG:65F1.5, anticorps appl, anticorps Abpp, anticorps Adap, anticorps Ag, anticorps Cvap, anticorps E030013M08Rik, anticorps betaApp, anticorps app, anticorps wu:fj34d10, anticorps wu:fk65e12, anticorps zgc:85740, anticorps amyloid beta precursor protein, anticorps amyloid beta (A4) precursor protein, anticorps beta amyloid protein precursor-like, anticorps amyloid beta (A4) precursor protein a, anticorps amyloid beta precursor protein L homeolog, anticorps APP, anticorps app, anticorps Appl, anticorps App, anticorps appa, anticorps app.L
    Sujet
    Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (A), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.
    Pathways
    Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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