BIM anticorps

N° du produit ABIN965669

Détail du produit anti-BIM anticorps

Antigène: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIM est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: BIM (Ab-69/65) antibody detects endogenous levels of total BIM protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from mouse BIM around the phosphorylation site of serine 69 (P-A-SP-P-G).

Information d'application

Indications d'application: IHC: 1:50-1:100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-BIM (ABIN965669)

Fukazawa, Noguchi, Masumi, Murakami, Uehara: "BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors." dans: Molecular cancer therapeutics, Vol. 3, Issue 10, pp. 1281-8, (2004) (PubMed).

Luciano, Jacquel, Colosetti, Herrant, Cagnol, Pages, Auberger: "Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function." dans: Oncogene, Vol. 22, Issue 43, pp. 6785-93, (2003) (PubMed).

Détails sur BIM

Antigène: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Autre désignation: BIM (BCL2L11 Produits)

Synonymes: anticorps bim, anticorps BAM, anticorps BIM, anticorps BOD, anticorps 1500006F24Rik, anticorps Bim, anticorps Bod, anticorps BimL, anticorps BIMEL, anticorps BCL2-like 11, anticorps BCL2 like 11, anticorps BCL2-like 11 (apoptosis facilitator), anticorps bcl2l11, anticorps BCL2L11, anticorps Bcl2l11

Pathways: Signalisation PI3K-Akt, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity