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BRAF anticorps

BRAF Reactivité: Humain WB, ELISA, IHC Hôte: Souris Monoclonal 1H12F1-1H12G10-1F12F11C9 unconjugated
N° du produit ABIN965693
  • Antigène Voir toutes BRAF Anticorps
    BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))
    Reactivité
    • 202
    • 72
    • 51
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 184
    • 18
    • 2
    Souris
    Clonalité
    • 168
    • 36
    Monoclonal
    Conjugué
    • 123
    • 13
    • 13
    • 10
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BRAF est non-conjugé
    Application
    • 115
    • 114
    • 70
    • 32
    • 30
    • 18
    • 13
    • 13
    • 9
    • 8
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of BRAF expressed in E. Coli.
    Clone
    1H12F1-1H12G10-1F12F11C9
    Isotype
    IgG1
    Top Product
    Discover our top product BRAF Anticorps primaire
  • Indications d'application
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • Kim, Giuliano, Turner, Gaffney, Umetani, Kitago, Elashoff, Hoon: "Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinoma." dans: Annals of surgery, Vol. 244, Issue 5, pp. 799-804, (2006) (PubMed).

    Terai, Matsuda: "The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf." dans: The EMBO journal, Vol. 25, Issue 15, pp. 3556-64, (2006) (PubMed).

    Noda, Kato, Yoshikawa, Arai, Togashi, Nagai, Konishi, Miki: "Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers." dans: Journal of experimental & clinical cancer research : CR, Vol. 25, Issue 2, pp. 235-42, (2006) (PubMed).

  • Antigène
    BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))
    Autre désignation
    BRAF (BRAF Produits)
    Synonymes
    anticorps B-RAF1, anticorps BRAF1, anticorps NS7, anticorps RAFB1, anticorps C-RMIL, anticorps RMIL, anticorps B-Raf, anticorps braf1, anticorps rafb1, anticorps b-raf1, anticorps sierrabraf, anticorps BRAF, anticorps 9930012E13Rik, anticorps AA120551, anticorps AA387315, anticorps AA473386, anticorps B-raf, anticorps Braf-2, anticorps Braf2, anticorps C230098H17, anticorps C87398, anticorps D6Ertd631e, anticorps braf, anticorps fc48g01, anticorps wu:fc48g01, anticorps B-Raf proto-oncogene, serine/threonine kinase, anticorps B-Raf proto-oncogene, serine/threonine kinase S homeolog, anticorps Braf transforming gene, anticorps si:dkey-222f8.3, anticorps BRAF, anticorps Braf, anticorps braf.S, anticorps braf, anticorps si:dkey-222f8.3
    Sujet
    BRAF(V-raf murine sarcoma viral oncogene homolog B1 ) is the main effectors recruited by GTP-bound Ras to activate the MEKMAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439).B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK),it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers.The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi,primary cutaneous melanomas and colorectal cancers.
    Synonyms: BRAF
    ID gène
    673
    Pathways
    Signalisation MAPK, Signalisation RTK, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy
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