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BRIP1 anticorps (C-Term)

BRIP1 Reactivité: Humain IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN965699
  • Antigène Voir toutes BRIP1 Anticorps
    BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))
    Épitope
    • 15
    • 9
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 60
    • 36
    • 14
    • 12
    • 12
    • 12
    • 12
    • 12
    Humain
    Hôte
    • 56
    • 3
    • 1
    Lapin
    Clonalité
    • 57
    • 3
    Polyclonal
    Conjugué
    • 21
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp BRIP1 est non-conjugé
    Application
    • 45
    • 24
    • 23
    • 13
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC)
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human BRIP1(ATP-dependent RNA helicase)
    Top Product
    Discover our top product BRIP1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Stock
    4 °C
  • Cantor, Drapkin, Zhang, Lin, Han, Pamidi, Livingston: "The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 8, pp. 2357-62, (2004) (PubMed).

    Yu, Chini, He, Mer, Chen: "The BRCT domain is a phospho-protein binding domain." dans: Science (New York, N.Y.), Vol. 302, Issue 5645, pp. 639-42, (2003) (PubMed).

  • Antigène
    BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))
    Autre désignation
    BRIP1 (BRIP1 Produits)
    Synonymes
    anticorps MGC68622, anticorps BRIP1, anticorps fancj, anticorps si:ch211-158l18.1, anticorps BACH1, anticorps FANCJ, anticorps OF, anticorps 3110009N10Rik, anticorps 8030460J03Rik, anticorps Bach1, anticorps FACJ, anticorps Fancj, anticorps BRCA1 interacting protein C-terminal helicase 1, anticorps BRCA1 interacting protein C-terminal helicase 1 L homeolog, anticorps Brip1, anticorps brip1.L, anticorps BRIP1, anticorps brip1
    Sujet
    BRIP1(ATP-dependent RNA helicase Is a DNA-dependent ATPase and 5' to 3' DNA helicase which is required for the maintenance of chromosomal stability. BRIP1 acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. BRIP1 is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. BRIP1 binds directly to the BRCT domains of BRCA1. BRIP1 is ubiquitously expressed, with highest levels in testis. Defects in BRIP1 are a cause of susceptibility to breast cancer (BC). BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
    Synonyms: FACJ (Fanconi anemia group J protein), BRCA1(interacting protein C-terminal helicase 1)
    Pathways
    Réparation de l'ADN
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