BTK anticorps

N° du produit ABIN965707

Détail du produit anti-BTK anticorps

Antigène: BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp BTK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: Ni-NTA purified truncated recombinant BTK expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Références pour anticorps anti-BTK (ABIN965707)

Tamagnone, Lahtinen, Mustonen, Virtaneva, Francis, Muscatelli, Alitalo, Smith, Larsson, Alitalo: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." dans: Oncogene, Vol. 9, Issue 12, pp. 3683-8, (1994) (PubMed).

Yamada, Kawakami, Kimura, Fukamachi, Baier, Altman, Kato, Inagaki, Kawakami: "Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells." dans: Biochemical and biophysical research communications, Vol. 192, Issue 1, pp. 231-40, (1993) (PubMed).

Thomas, Sideras, Smith, Vorechovský, Chapman, Paul: "Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes." dans: Science (New York, N.Y.), Vol. 261, Issue 5119, pp. 355-8, (1993) (PubMed).

Détails sur BTK

Antigène: BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

Autre désignation: BTK (BTK Produits)

Synonymes: anticorps BTK, anticorps atk, anticorps bpk, anticorps xla, anticorps imd1, anticorps agmx1, anticorps psctk1, anticorps AGMX1, anticorps AT, anticorps ATK, anticorps BPK, anticorps IMD1, anticorps PSCTK1, anticorps XLA, anticorps AI528679, anticorps xid, anticorps Bruton tyrosine kinase, anticorps Bruton agammaglobulinemia tyrosine kinase, anticorps BTK, anticorps btk, anticorps Btk

Sujet: Brutons tyrosine kinase (BTK) is a member of the BTK/ Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

ID gène: 695

Pathways: Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling