C-Abl (Ab-412) antibody detects endogenous levels of total c-Abl protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogène
The antiserum was produced against synthesized non-phosphopeptide derived from human c-Abl around the phosphorylation site of tyrosine 412 (D-T-YP-T-A).
ABL1
Reactivité: Humain
IHC (p), DB
Hôte: Lapin
Polyclonal
RB7343
unconjugated
Indications d'application
IHC: 1:50-1:100.
Restrictions
For Research Use only
Format
Liquid
Concentration
100ug/100ul.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Kawai, Nie, Yuan: "Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl." dans: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6079-88, (2002) (PubMed).
Yoshida, Komatsu, Wang, Kufe: "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage." dans: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3292-300, (2002) (PubMed).
Sionov, Coen, Goldberg, Berger, Bercovich, Ben-Neriah, Ciechanover, Haupt: "c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination." dans: Molecular and cellular biology, Vol. 21, Issue 17, pp. 5869-78, (2001) (PubMed).
Kharbanda, Pandey, Yamauchi, Kumar, Kaneki, Kumar, Bharti, Yuan, Ghanem, Rana, Weichselbaum, Johnson, Kufe: "Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage." dans: Molecular and cellular biology, Vol. 20, Issue 14, pp. 4979-89, (2000) (PubMed).