CD80 anticorps (N-Term)

N° du produit ABIN965820

Détail du produit anti-CD80 anticorps

Antigène: CD80

Épitope: AA 57-71, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD80 est non-conjugé

Application: Western Blotting (WB)

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminal of human CD80 (57-71aa), identical to the related mouse and rat sequence.

Information d'application

Indications d'application: WB: The detection limit for CD80/ B7-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Stock: -20 °C

Références pour anticorps anti-CD80 (ABIN965820)

Stamper, Zhang, Tobin, Erbe, Ikemizu, Davis, Stahl, Seehra, Somers, Mosyak: "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses." dans: Nature, Vol. 410, Issue 6828, pp. 608-11, (2001) (PubMed).

Peach, Bajorath, Naemura, Leytze, Greene, Aruffo, Linsley: "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28." dans: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21181-7, (1995) (PubMed).

Détails sur CD80

Antigène: CD80

Autre désignation: CD80 (CD80 Produits)

Synonymes: anticorps B7, anticorps B7-1, anticorps B7.1, anticorps BB1, anticorps CD28LG, anticorps CD28LG1, anticorps LAB7, anticorps B71, anticorps Cd28l, anticorps Ly-53, anticorps Ly53, anticorps MIC17, anticorps TSA1, anticorps CD80 molecule, anticorps Cd80 molecule, anticorps CD80 antigen, anticorps CD80, anticorps Cd80

Sujet: Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints