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E-cadherin anticorps

CDH1 Reactivité: Humain, Souris, Singe WB, ELISA Hôte: Souris Monoclonal 7H12 unconjugated
N° du produit ABIN965838
  • Antigène Voir toutes E-cadherin (CDH1) Anticorps
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Reactivité
    • 251
    • 103
    • 87
    • 18
    • 17
    • 16
    • 9
    • 9
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Singe
    Hôte
    • 202
    • 83
    • 8
    • 7
    Souris
    Clonalité
    • 188
    • 111
    • 1
    Monoclonal
    Conjugué
    • 141
    • 36
    • 29
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp E-cadherin est non-conjugé
    Application
    • 207
    • 94
    • 92
    • 68
    • 57
    • 56
    • 39
    • 35
    • 29
    • 27
    • 17
    • 16
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human CDH1 expressed in E. Coli.
    Clone
    7H12
    Isotype
    IgG1
    Top Product
    Discover our top product CDH1 Anticorps primaire
  • Indications d'application
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    Flow cytometry: 1/200 - 1/400.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • Schietke, Warnecke, Wacker, Schödel, Mole, Campean, Amann, Goppelt-Struebe, Behrens, Eckardt, Wiesener: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." dans: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, (2010) (PubMed).

    Barrett, Lee, Lees, Prescott, Anderson, Phillips, Wesley, Parnell, Zhang, Drummond, Nimmo, Massey, Blaszczyk, Elliott, Cotterill, Dallal, Lobo, Mowat, Sanderson, Jewell, Newman, Edwards, Ahmad et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." dans: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, (2009) (PubMed).

    Rigby: "Statistical reviewing for disability and rehabilitation." dans: Disability and rehabilitation, Vol. 31, Issue 7, pp. 515-21, (2009) (PubMed).

  • Antigène
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Autre désignation
    CDH1 (CDH1 Produits)
    Synonymes
    anticorps Arc-1, anticorps CD324, anticorps CDHE, anticorps ECAD, anticorps LCAM, anticorps UVO, anticorps E-cadherin, anticorps cdh1, anticorps si:dz180o5.2, anticorps uvo, anticorps lcam, anticorps E-Cad, anticorps XBcad, anticorps l-cam, anticorps xcdh1, anticorps cdhc-A, anticorps xb-cad, anticorps XTCAD-1, anticorps c-cadherin, anticorps cadherin-1, anticorps uvomorulin, anticorps XB-cadherin, anticorps arc-1, anticorps cd324, anticorps cdhe, anticorps ecad, anticorps AA960649, anticorps E-cad, anticorps Ecad, anticorps L-CAM, anticorps Um, anticorps cadherin 1, anticorps si:busm1-180o5.2, anticorps cadherin 1, type 1, E-cadherin (epithelial), anticorps cadherin 1, type 1 S homeolog, anticorps CDH1, anticorps si:busm1-180o5.2, anticorps cdh1, anticorps Cdh1, anticorps cdh1.S
    Sujet
    E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calciumdependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.
    Tissue specificity: Non-neural epithelial tissues.
    Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
    Poids moléculaire
    135kDa
    ID gène
    999
    Pathways
    Signalisation WNT, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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