CHEK1
Reactivité: Humain, Souris, Rat
IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot: Dilution 1: 2,00- 1: 1,000 ELISA: Propose dilution 1: 10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Stock
-20 °C
OConnell, Raleigh, Verkade, Nurse: "Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation." dans: The EMBO journal, Vol. 16, Issue 3, pp. 545-54, (1997) (PubMed).
Active recombinant full length human CHK1 containing an Nterminal GST tag. This protein has an apparent molecular weight of ~82kDa. CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia.