CHEK1 anticorps

N° du produit ABIN965885

Détail du produit anti-CHEK1 anticorps

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHEK1 est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: Chk1 (Ab-317) antibody detects endogenous levels of total Chk1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from human Chk1 around the phosphorylation site of serine 317 (S-S-SP-Q-P)

Information d'application

Indications d'application: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-CHEK1 (ABIN965885)

Zhang, Otterness, Chiang, Xie, Liu, Mercurio, Abraham: "Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway." dans: Molecular cell, Vol. 19, Issue 5, pp. 607-18, (2005) (PubMed).

Rocha, Garrett, Campbell, Schumm, Perkins: "Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor." dans: The EMBO journal, Vol. 24, Issue 6, pp. 1157-69, (2005) (PubMed).

Clarke, Clarke: "DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system." dans: The Biochemical journal, Vol. 388, Issue Pt 2, pp. 705-12, (2005) (PubMed).

Yu, Chen: "DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains." dans: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9478-86, (2004) (PubMed).

Détails sur CHEK1

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Autre désignation: CHK1 (CHEK1 Produits)

Synonymes: anticorps An08g10320, anticorps AO090003000441, anticorps CHK1, anticorps chk1, anticorps C85740, anticorps Chk1, anticorps rad27, anticorps id:ibd2720, anticorps zgc:56093, anticorps CHEK1, anticorps checkpoint kinase 1, anticorps serine/threonine-protein kinase chk1, anticorps serine/threonine-protein kinase Chk1, anticorps CAMK/CAMKL/CHK1 protein kinase Chk1, anticorps checkpoint kinase 1 S homeolog, anticorps CHEK1, anticorps ANI_1_2436074, anticorps AOR_1_768154, anticorps PTRG_04183, anticorps SJAG_01680, anticorps PAAG_04978, anticorps MCYG_03290, anticorps VDBG_03742, anticorps chek1.S, anticorps Chek1, anticorps chek1

Pathways: Signalisation p53, Apoptose, Cycle Cellulaire, Réparation de l'ADN