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KRT17 anticorps

KRT17 Reactivité: Humain WB, IHC, ELISA Hôte: Souris Monoclonal 3B12 unconjugated
N° du produit ABIN965900
  • Antigène Voir toutes KRT17 Anticorps
    KRT17 (Keratin 17 (KRT17))
    Reactivité
    • 124
    • 47
    • 29
    • 18
    • 13
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 100
    • 35
    Souris
    Clonalité
    • 87
    • 48
    Monoclonal
    Conjugué
    • 57
    • 16
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KRT17 est non-conjugé
    Application
    • 103
    • 44
    • 38
    • 31
    • 27
    • 26
    • 22
    • 20
    • 18
    • 15
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of CK17 expressed in E. Coli.
    Clone
    3B12
    Isotype
    IgG2b
    Top Product
    Discover our top product KRT17 Anticorps primaire
  • Indications d'application
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • van de Rijn, Perou, Tibshirani, Haas, Kallioniemi, Kononen, Torhorst, Sauter, Zuber, Köchli, Mross, Dieterich, Seitz, Ross, Botstein, Brown: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." dans: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).

    Leigh, Navsaria, Purkis, McKay, Bowden, Riddle: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." dans: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, (1995) (PubMed).

  • Antigène
    KRT17 (Keratin 17 (KRT17))
    Autre désignation
    CK17 (KRT17 Produits)
    Synonymes
    anticorps K17, anticorps Krt1-17, anticorps PC, anticorps PC2, anticorps PCHC1, anticorps Ka17, anticorps KRT17, anticorps krt16, anticorps si:dkeyp-113d7.7, anticorps KRT14, anticorps keratin 17, anticorps keratin 17 L homeolog, anticorps keratin 17, type I, anticorps keratin, type I cytoskeletal 17, anticorps Krt17, anticorps KRT17, anticorps krt17, anticorps krt17.L, anticorps LOC100737113, anticorps LOC102177275
    Sujet
    CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
    Synonyms: PC, K17, PC2, PCHC1, KRT17
    Poids moléculaire
    49kDa
    ID gène
    3872
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