DCLRE1C anticorps

N° du produit ABIN965976

Détail du produit anti-DCLRE1C anticorps

Antigène: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLRE1C est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human DCLRE1C (DNA cross-link repair 1C protein)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-DCLRE1C (ABIN965976)

Pannicke, Ma, Hopfner, Niewolik, Lieber, Schwarz: "Functional and biochemical dissection of the structure-specific nuclease ARTEMIS." dans: The EMBO journal, Vol. 23, Issue 9, pp. 1987-97, (2004) (PubMed).

Poinsignon, de Chasseval, Soubeyrand, Moshous, Fischer, Haché, de Villartay: "Phosphorylation of Artemis following irradiation-induced DNA damage." dans: European journal of immunology, Vol. 34, Issue 11, pp. 3146-55, (2004) (PubMed).

Poinsignon, Moshous, Callebaut, de Chasseval, Villey, de Villartay: "The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination." dans: The Journal of experimental medicine, Vol. 199, Issue 3, pp. 315-21, (2004) (PubMed).

Ma, Lu, Tippin, Goodman, Shimazaki, Koiwai, Hsieh, Schwarz, Lieber: "A biochemically defined system for mammalian nonhomologous DNA end joining." dans: Molecular cell, Vol. 16, Issue 5, pp. 701-13, (2004) (PubMed).

Ma, Pannicke, Schwarz, Lieber: "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination." dans: Cell, Vol. 108, Issue 6, pp. 781-94, (2002) (PubMed).

Callebaut, Moshous, Mornon, de Villartay: "Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family." dans: Nucleic acids research, Vol. 30, Issue 16, pp. 3592-601, (2002) (PubMed).

Moshous, Callebaut, de Chasseval, Corneo, Cavazzana-Calvo, Le Deist, Tezcan, Sanal, Bertrand, Philippe, Fischer, de Villartay: "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency." dans: Cell, Vol. 105, Issue 2, pp. 177-86, (2001) (PubMed).

Détails sur DCLRE1C

Antigène: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Autre désignation: DCLRE1C (DCLRE1C Produits)

Synonymes: anticorps artemis, anticorps A-SCID, anticorps DCLREC1C, anticorps RS-SCID, anticorps SCIDA, anticorps SNM1C, anticorps hSNM1C, anticorps Snm1l, anticorps nuclease, anticorps 9930121L06Rik, anticorps AI661365, anticorps Art, anticorps DNA cross-link repair 1C, anticorps DCLRE1C, anticorps Dclre1c

Sujet: DCLRE1C (DNA cross-link repair 1C protein) is required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Synonyms: ARTEMIS, ASCID, SCIDA, SNM1C

Pathways: Réparation de l'ADN