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DDX58 anticorps (N-Term)

DDX58 Reactivité: Humain IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN965985
  • Antigène Voir toutes DDX58 Anticorps
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    Épitope
    • 15
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 65
    • 42
    • 17
    • 2
    • 1
    Humain
    Hôte
    • 59
    • 9
    • 1
    • 1
    Lapin
    Clonalité
    • 61
    • 9
    Polyclonal
    Conjugué
    • 37
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DDX58 est non-conjugé
    Application
    • 61
    • 19
    • 14
    • 14
    • 14
    • 11
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    Immunohistochemistry (IHC)
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DDX58 (Probable ATP-dependent RNA helicase DDX58)
    Top Product
    Discover our top product DDX58 Anticorps primaire
  • Restrictions
    For Research Use only
  • Stock
    4 °C
  • Seth, Sun, Ea, Chen: "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." dans: Cell, Vol. 122, Issue 5, pp. 669-82, (2005) (PubMed).

    Huang, Liu, Xu, Chen, Zhai, Shu: "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways." dans: The EMBO journal, Vol. 24, Issue 23, pp. 4018-28, (2005) (PubMed).

    Sumpter, Loo, Foy, Li, Yoneyama, Fujita, Lemon, Gale: "Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I." dans: Journal of virology, Vol. 79, Issue 5, pp. 2689-99, (2005) (PubMed).

    Cui, Imaizumi, Yoshida, Borden, Satoh: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." dans: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, (2004) (PubMed).

    Imaizumi, Aratani, Nakajima, Carlson, Matsumiya, Tanji, Ookawa, Yoshida, Tsuchida, McIntyre, Prescott, Zimmerman, Satoh: "Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2." dans: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 274-9, (2002) (PubMed).

  • Antigène
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    Autre désignation
    DDX58 (DDX58 Produits)
    Synonymes
    anticorps RIG-I, anticorps RIGI, anticorps RLR-1, anticorps 6430573D20Rik, anticorps C330021E21, anticorps RHIV-1, anticorps RIG-1, anticorps DExD/H-box helicase 58, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, anticorps DEXD/H-box helicase 58, anticorps DDX58, anticorps Ddx58
    Sujet
    DDX58 (Probable ATP-dependent RNA helicase DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58 (Probable ATP-dependent RNA helicase DDX58) is maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. Interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING. DDX58 (Probable ATP-dependent RNA helicase DDX58) is present in vascular smooth cells at protein level. DDX58 belongs to the helicase family and contains 2 CARD domains, 1 helicase ATP-binding domain and 1 helicase C-terminal domain.
    Synonyms: DEAD-box protein 58, RIG-1 (Retinoic acid-inducible gene 1 protein)
    Pathways
    Activation of Innate immune Response, Hepatitis C
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