DERL1 anticorps (N-Term)

N° du produit ABIN965990

Détail du produit anti-DERL1 anticorps

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DERL1 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur DERL1

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Autre désignation: DERL1 (DERL1 Produits)

Synonymes: anticorps CG10908, anticorps Dmel\\CG10908, anticorps DDBDRAFT_0188135, anticorps DDBDRAFT_0266772, anticorps DDB_0188135, anticorps DDB_0266772, anticorps MGC84200, anticorps wu:fb09d07, anticorps wu:fb94d05, anticorps wu:fj92g12, anticorps zgc:55637, anticorps 1110021N07Rik, anticorps AI195141, anticorps AW551338, anticorps Derlin-1, anticorps derlin-1, anticorps DER-1, anticorps DER1, anticorps RGD1311835, anticorps DERLIN-1, anticorps F17A13.150, anticorps F17A13_150, anticorps Derlin-1, anticorps derlin-1, anticorps derlin-1.1, anticorps hypothetical protein, anticorps Der1-like domain family, member 1, anticorps derlin 1, anticorps derlin 1 L homeolog, anticorps DERLIN-1, anticorps Der-1, anticorps EDI_023440, anticorps PTRG_01331, anticorps derl1, anticorps DERL1, anticorps derl1.L, anticorps Derl1, anticorps DER1

Sujet: DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.

Pathways: ER-Nucleus Signaling