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DISC1 anticorps (N-Term)

DISC1 Reactivité: Humain IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN965999
  • Antigène Voir toutes DISC1 Anticorps
    DISC1 (Disrupted in Schizophrenia 1 (DISC1))
    Épitope
    • 15
    • 14
    • 7
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 70
    • 25
    • 14
    • 1
    Humain
    Hôte
    • 69
    • 4
    • 1
    • 1
    Lapin
    Clonalité
    • 71
    • 6
    Polyclonal
    Conjugué
    • 42
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DISC1 est non-conjugé
    Application
    • 48
    • 31
    • 25
    • 14
    • 14
    • 11
    • 11
    • 8
    • 6
    • 5
    • 5
    • 3
    • 1
    Immunohistochemistry (IHC)
    Purification
    Purified by antigen-specific affinity chromatography.
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DISC1 (Disrupted in schizophrenia 1 protein)
    Top Product
    Discover our top product DISC1 Anticorps primaire
  • Indications d'application
    ELISA, Western blotting: 1µg/ml for 2hrs.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    This antibody is stored in PBS, 50% glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    DISC1 (Disrupted in Schizophrenia 1 (DISC1))
    Autre désignation
    DISC1 (Disrupted in schizophrenia 1 protein) (DISC1 Produits)
    Synonymes
    anticorps DISC1, anticorps C1orf136, anticorps SCZD9, anticorps disrupted in schizophrenia 1, anticorps disrupted in schizophrenia 1 protein, anticorps disc1, anticorps DISC1, anticorps LOC100580606, anticorps Disc1
    Sujet
    Disrupted-In-Schizophrenia 1 (DISC1) is associated with schizophrenia by multiple genetic studies. DISC1 might cause susceptibility to schizophrenia. DISC1 has distinct interaction domains: MAP1A interacts via its LC2 domain with the N-terminus of DISC1, whereas MIPT3 and NUDEL bind via their C-terminal domains to the central coiled-coil domain of DISC1, and ATF4/5 bind via their C-terminal domains to the C-terminus of DISC1. DISC1 protein localizes to predominantly perinuclear punctate structures which extend into neurites in some cells. DISC1 is a multifunctional protein whose truncation contributes to schizophrenia susceptibility by disrupting intracellular transport, neurite architecture and/or neuronal migration, all of which have been hypothesized to be pathogenic in the schizophrenic brain. DISC1 interacts with Nudel through a leucine zipper domain and binds to a novel DISC1-interaction domain on Nudel, which is independent from the Lis1 binding site. Nudel is able to act as a bridge between DISC1 and Lis1 to allow formation of a trimolecular complex. Nudel has been implicated to play a role in neuronal migration, together with the developmental variation in the abundance of the DISC1-Nudel complex, may implicate a defective DISC1-Nudel complex as a neurodevelopmental cause of schizophrenia.
    Pathways
    Regulation of Cell Size
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