Dvl-B (C-Term) anticorps

N° du produit ABIN966016

Détail du produit

Antigène: Dvl-B

Épitope: C-Term

Reactivité: Freshwater Flatworm (Schmidtea mediterranea)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Freshwater Flatworms Schmidtea mediterranea Dvl-b (Dishevelled-like protein)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Référence

Gurley, Rink, Sánchez Alvarado: "Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis." dans: Science (New York, N.Y.), Vol. 319, Issue 5861, pp. 323-7, (2008) (PubMed).

Détail du antigène

Antigène: Dvl-B

Sujet: Dvl-b (Dishevelled-like protein) contains PDZ_signaling domain and DEP_dishevelled domain. PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. It may be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-Cterminal). DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway.