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Exonuclease 1 anticorps (N-Term)

EXO1 Reactivité: Humain, Souris IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN966108
  • Antigène Voir toutes Exonuclease 1 (EXO1) Anticorps
    Exonuclease 1 (EXO1)
    Épitope
    • 16
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 45
    • 26
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 42
    • 4
    • 1
    Lapin
    Clonalité
    • 44
    • 3
    Polyclonal
    Conjugué
    • 27
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Exonuclease 1 est non-conjugé
    Application
    • 42
    • 15
    • 14
    • 13
    • 13
    • 10
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Purification
    Purified by antigen-specific affinity chromatography.
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human exonuclease 1
    Top Product
    Discover our top product EXO1 Anticorps primaire
  • Indications d'application
    ELISA, Western blotting: 1µg/ml for 2hrs.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    This antibody is stored in PBS, 50% glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Genschel, Modrich: "Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair." dans: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21536-44, (2009) (PubMed).

    Sharma, Sommers, Driscoll, Uzdilla, Wilson, Brosh: "The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein." dans: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23487-96, (2003) (PubMed).

  • Antigène
    Exonuclease 1 (EXO1)
    Autre désignation
    EXO1 (EXO1 Produits)
    Synonymes
    anticorps HEX1, anticorps hExoI, anticorps 5730442G03Rik, anticorps Msa, anticorps EXO1, anticorps exoi, anticorps fc16e04, anticorps wu:fc16e04, anticorps zgc:55521, anticorps exonuclease 1, anticorps hypothetical protein, anticorps exonuclease I Exo1, anticorps RNA exonuclease, anticorps exonuclease 1 S homeolog, anticorps EXO1, anticorps Y17G7B.12, anticorps SJAG_01832, anticorps PAS_chr1-1_0377, anticorps Exo1, anticorps exo1, anticorps exo1.S, anticorps LOC100338764
    Sujet
    EXO1 (exonuclease 1) is a 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. EXO1 functions in DNA mismatch repair (MMR) to excise mismatchcontaining DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5' overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5' end of a downstream Okazaki fragment. EXO1 is required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. It is essential for male and female meiosis. EXO1 interacts with the MLH1-PMS2 heterodimer via MLH1. It interacts with MSH3 and with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'->3' exonuclease activity. EXO1 interacts with PCNA, and this interaction may both stimulate the cryptic 3'->5' exonuclease activity and suppress the 5'->3' exonuclease activity. EXO1 interacts with WRN, and this interaction stimulates both the 5'->3' exonuclease activity and cleavage of 5' overhanging flap structures. It also interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5' overhanging flap structures.
    Pathways
    Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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