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FANCD2 anticorps (Isoform B)

FANCD2 Reactivité: Humain, Souris IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN966127
  • Antigène Voir toutes FANCD2 Anticorps
    FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))
    Épitope
    • 16
    • 15
    • 15
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform B
    Reactivité
    • 102
    • 25
    • 22
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 101
    • 2
    Lapin
    Clonalité
    • 91
    • 12
    Polyclonal
    Conjugué
    • 35
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp FANCD2 est non-conjugé
    Application
    • 29
    • 27
    • 27
    • 24
    • 16
    • 14
    • 12
    • 9
    • 8
    • 7
    • 6
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human FANCD2 (Fanconi anemia complementation group D2 isoform b)
    Top Product
    Discover our top product FANCD2 Anticorps primaire
  • Restrictions
    For Research Use only
  • Stock
    4 °C
  • Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." dans: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, (2009) (PubMed).

    Singh, Bakker, Agarwal, Jansen, Grassman, Godthelp, Ali, Du, Rooimans, Fan, Wahengbam, Steltenpool, Andreassen, Williams, Joenje, de Winter, Meetei: "Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M." dans: Blood, Vol. 114, Issue 1, pp. 174-80, (2009) (PubMed).

    Kuhnert, Kachnic, Li, Purschke, Gheorghiu, Lee, Held, Willers: "FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions." dans: International journal of radiation biology, Vol. 85, Issue 6, pp. 523-31, (2009) (PubMed).

    Chan, Palmai-Pallag, Ying, Hickson: "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis." dans: Nature cell biology, Vol. 11, Issue 6, pp. 753-60, (2009) (PubMed).

  • Antigène
    FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))
    Autre désignation
    FANCD2 (FANCD2 Produits)
    Synonymes
    anticorps FANCD2, anticorps CG17269, anticorps CG31192, anticorps CG31194, anticorps Dmel\\CG17269, anticorps dmFANCD2, anticorps xfancd2, anticorps FA-D2, anticorps FA4, anticorps FACD, anticorps FAD, anticorps FAD2, anticorps FANCD, anticorps 2410150O07Rik, anticorps AU015151, anticorps BB137857, anticorps Fanconi anemia complementation group D2, anticorps CG17269 gene product from transcript CG17269-RA, anticorps Fanconi anemia group D2 protein, anticorps Fanconi anemia, complementation group D2, anticorps Fanconi anemia complementation group D2 L homeolog, anticorps FANCD2, anticorps Fancd2, anticorps LOC100455970, anticorps fancd2, anticorps fancd2.L
    Sujet
    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homologydirected DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
    Pathways
    Réparation de l'ADN
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